Drug interactions
Flibanserin + Naldemedine
Severity: Moderate
Flibanserin and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits P-glycoprotein and may raise naldemedine concentrations. This could increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Flibanserin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal P-gp efflux of naldemedine by flibanserin.
What to do
Monitor for naldemedine adverse effects such as abdominal pain and diarrhea, and reduce or stop naldemedine if they become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Flibanserin with Naldemedine?
MediHelp rates the interaction as moderate. Flibanserin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin inhibits P-glycoprotein and may raise naldemedine concentrations. This could increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Flibanserin and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for naldemedine adverse effects such as abdominal pain and diarrhea, and reduce or stop naldemedine if they become troublesome.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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