Drug interactions
Flibanserin + Orphenadrin
Severity: Moderate
Flibanserin and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin exposure rises with CYP3A4 inhibition, and orphenadrine is described as a weak CYP3A4 inhibitor. The clinical effect is probably small alone, but flibanserin can cause hypotension, syncope and sedation, and these are more likely with additional CNS depressants.
What this interaction means in plain words
Flibanserin and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Orphenadrin belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition by orphenadrine raising flibanserin levels, plus additive sedation.
What to do
Counsel the patient about dizziness, drowsiness and syncope, and advise avoiding alcohol. Monitor blood pressure and sedation, and reduce use of other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Orphenadrin?
MediHelp rates the interaction as moderate. Flibanserin and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin exposure rises with CYP3A4 inhibition, and orphenadrine is described as a weak CYP3A4 inhibitor. The clinical effect is probably small alone, but flibanserin can cause hypotension, syncope and sedation, and these are more likely with additional CNS depressants.
How serious is the interaction between Flibanserin and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness, drowsiness and syncope, and advise avoiding alcohol. Monitor blood pressure and sedation, and reduce use of other CNS depressants.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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