Drug interactions
Flibanserin + Quetiapine
Severity: Moderate
Flibanserin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on central nervous system pathways and both can cause sedation, hypotension and syncope. A theoretical additive risk of serotonergic or dopamine-blocking toxicity also exists, although documented cases are scarce.
What this interaction means in plain words
Flibanserin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects, with a theoretical pharmacodynamic overlap on serotonergic and dopaminergic signalling.
What to do
Monitor for excessive sedation, orthostatic hypotension and syncope, especially after starting or changing doses. Counsel the patient to avoid driving and to report fever, rigidity or agitation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Flibanserin with Quetiapine?
MediHelp rates the interaction as moderate. Flibanserin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on central nervous system pathways and both can cause sedation, hypotension and syncope. A theoretical additive risk of serotonergic or dopamine-blocking toxicity also exists, although documented cases are scarce.
How serious is the interaction between Flibanserin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, orthostatic hypotension and syncope, especially after starting or changing doses. Counsel the patient to avoid driving and to report fever, rigidity or agitation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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