Drug interactions
Flibanserin + Ramelteon
Severity: Minor
Flibanserin and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is a sedative-hypnotic and flibanserin also causes somnolence. Taken together, they may increase daytime drowsiness and dizziness, particularly when flibanserin is taken at bedtime.
What this interaction means in plain words
Flibanserin and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flibanserin belongs to Genitourinary; Ramelteon belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic sedation; ramelteon acts as a melatonin receptor agonist with milder CNS depression.
What to do
Advise the patient to watch for additive drowsiness and avoid driving if impaired. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Flibanserin with Ramelteon?
MediHelp rates the interaction as minor. Flibanserin and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is a sedative-hypnotic and flibanserin also causes somnolence. Taken together, they may increase daytime drowsiness and dizziness, particularly when flibanserin is taken at bedtime.
How serious is the interaction between Flibanserin and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to watch for additive drowsiness and avoid driving if impaired. No routine dose change is needed.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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