Drug interactions
Flibanserin + Sufentanil
Severity: Major
Flibanserin and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid and flibanserin adds sedation and hypotension. The combination increases the risk of profound CNS and respiratory depression and low blood pressure.
What this interaction means in plain words
Flibanserin and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flibanserin belongs to Genitourinary; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS and respiratory depression and hypotension.
What to do
Monitor respiratory function, sedation and blood pressure closely, and reduce the opioid dose as needed. In perioperative settings, consider timing of flibanserin dosing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Flibanserin with Sufentanil?
MediHelp rates the interaction as major. Flibanserin and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a potent opioid and flibanserin adds sedation and hypotension. The combination increases the risk of profound CNS and respiratory depression and low blood pressure.
How serious is the interaction between Flibanserin and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory function, sedation and blood pressure closely, and reduce the opioid dose as needed. In perioperative settings, consider timing of flibanserin dosing.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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