Drug interactions
Flibanserin + Tranylcypromine
Severity: Major
Flibanserin and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine is a non-selective MAO inhibitor, and combining it with a serotonergic agent like flibanserin raises concern for serotonin syndrome and hypotension. The legacy CYP3A4 rationale is not well established.
What this interaction means in plain words
Flibanserin and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flibanserin belongs to Genitourinary; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive serotonergic and hypotensive effects from MAO inhibition combined with flibanserin's serotonergic activity.
What to do
Avoid the combination where possible. If both are required, monitor for serotonin toxicity, hypotension and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Flibanserin with Tranylcypromine?
MediHelp rates the interaction as major. Flibanserin and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine is a non-selective MAO inhibitor, and combining it with a serotonergic agent like flibanserin raises concern for serotonin syndrome and hypotension. The legacy CYP3A4 rationale is not well established.
How serious is the interaction between Flibanserin and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor for serotonin toxicity, hypotension and sedation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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