Drug interactions
Flibanserin + Ziprasidone
Severity: Moderate
Flibanserin and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, orthostatic hypotension and syncope, so these effects may be additive. Ziprasidone is not a meaningful CYP3A4 inhibitor, though a theoretical serotonergic and dopaminergic overlap exists.
What this interaction means in plain words
Flibanserin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects, with theoretical pharmacodynamic overlap on serotonergic and dopaminergic pathways.
What to do
Monitor for sedation, dizziness and low blood pressure. Warn the patient to report fever, rigidity or confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Flibanserin with Ziprasidone?
MediHelp rates the interaction as moderate. Flibanserin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, orthostatic hypotension and syncope, so these effects may be additive. Ziprasidone is not a meaningful CYP3A4 inhibitor, though a theoretical serotonergic and dopaminergic overlap exists.
How serious is the interaction between Flibanserin and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and low blood pressure. Warn the patient to report fever, rigidity or confusion.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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