Drug interactions
Fluconazole + Fludrocortisone
Severity: Moderate
Fluconazole and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is metabolized in part by CYP3A4, and fluconazole may increase its exposure. This could heighten mineralocorticoid effects such as hypokalemia, fluid retention and hypertension.
What this interaction means in plain words
Fluconazole and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Fludrocortisone belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4, reducing fludrocortisone clearance.
What to do
Monitor blood pressure, edema and serum potassium. Adjust the fludrocortisone dose if signs of excess appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fluconazole with Fludrocortisone?
MediHelp rates the interaction as moderate. Fluconazole and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone is metabolized in part by CYP3A4, and fluconazole may increase its exposure. This could heighten mineralocorticoid effects such as hypokalemia, fluid retention and hypertension.
How serious is the interaction between Fluconazole and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium. Adjust the fludrocortisone dose if signs of excess appear.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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