Drug interactions
Fluconazole + Flurbiprofen
Severity: Moderate
Fluconazole and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9 and can increase flurbiprofen exposure, raising the risk of NSAID adverse effects such as GI bleeding and renal toxicity.
What this interaction means in plain words
Fluconazole and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Fluconazole inhibition of CYP2C9-mediated flurbiprofen metabolism.
What to do
Use the lowest effective flurbiprofen dose and monitor for GI and renal adverse effects. Consider reducing the NSAID dose during prolonged fluconazole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Flurbiprofen?
MediHelp rates the interaction as moderate. Fluconazole and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C9 and can increase flurbiprofen exposure, raising the risk of NSAID adverse effects such as GI bleeding and renal toxicity.
How serious is the interaction between Fluconazole and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurbiprofen dose and monitor for GI and renal adverse effects. Consider reducing the NSAID dose during prolonged fluconazole therapy.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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