Drug interactions
Fluconazole + Fluticasone-vilanterol
Severity: Moderate
Fluconazole and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval, and vilanterol may add to this effect. Fluconazole is a moderate CYP3A4 inhibitor that could raise inhaled fluticasone and vilanterol exposure, though less than strong inhibitors.
What this interaction means in plain words
Fluconazole and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QTc prolongation and CYP3A4 inhibition by fluconazole increasing exposure to both inhaled components.
What to do
Monitor for palpitations and, in patients at risk, ECG and potassium during fluconazole courses. Watch for systemic corticosteroid effects with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Fluconazole and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval, and vilanterol may add to this effect. Fluconazole is a moderate CYP3A4 inhibitor that could raise inhaled fluticasone and vilanterol exposure, though less than strong inhibitors.
How serious is the interaction between Fluconazole and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and, in patients at risk, ECG and potassium during fluconazole courses. Watch for systemic corticosteroid effects with prolonged use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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