Drug interactions
Fluconazole + Fluvastatin
Severity: Moderate
Fluconazole and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises fluvastatin exposure because fluvastatin is mainly metabolized by CYP2C9. This increases the risk of myopathy and, rarely, rhabdomyolysis.
What this interaction means in plain words
Fluconazole and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Fluvastatin belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP2C9-mediated fluvastatin metabolism.
What to do
Use the lowest effective fluvastatin dose, as labeling advises limiting the dose with fluconazole. Counsel patients to report muscle pain or weakness, and check CK if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluconazole with Fluvastatin?
MediHelp rates the interaction as moderate. Fluconazole and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole raises fluvastatin exposure because fluvastatin is mainly metabolized by CYP2C9. This increases the risk of myopathy and, rarely, rhabdomyolysis.
How serious is the interaction between Fluconazole and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose, as labeling advises limiting the dose with fluconazole. Counsel patients to report muscle pain or weakness, and check CK if symptomatic.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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