Drug interactions
Fluconazole + Glipizide-metformin
Severity: Major
Fluconazole and Glipizide-metformin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises glipizide exposure, which can cause prolonged or severe hypoglycemia. The effect is well documented with sulfonylureas metabolized by CYP2C9.
What this interaction means in plain words
Fluconazole and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glipizide-metformin belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP2C9, the main enzyme metabolizing glipizide, increasing sulfonylurea concentrations.
What to do
Monitor blood glucose closely during and after fluconazole therapy and reduce the glipizide dose if needed. Counsel the patient on hypoglycemia symptoms, and consider an alternative antifungal or antidiabetic agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Glipizide-metformin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Glipizide-metformin?
MediHelp rates the interaction as major. Fluconazole and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises glipizide exposure, which can cause prolonged or severe hypoglycemia. The effect is well documented with sulfonylureas metabolized by CYP2C9.
How serious is the interaction between Fluconazole and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after fluconazole therapy and reduce the glipizide dose if needed. Counsel the patient on hypoglycemia symptoms, and consider an alternative antifungal or antidiabetic agent.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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