Drug interactions
Fluconazole + Glyburide-metformin
Severity: Major
Fluconazole and Glyburide-metformin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises glyburide concentrations and has been associated with significant hypoglycemia. The effect may be prolonged because fluconazole has a long half-life.
What this interaction means in plain words
Fluconazole and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 (and CYP3A4) metabolism of glyburide.
What to do
Monitor blood glucose closely during and after fluconazole therapy and reduce the glyburide dose in advance if possible. Consider an alternative antifungal or antidiabetic agent for prolonged courses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluconazole and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Canesten Thrush Oral Capsule 150mg capsule - SmPC sections 4.3/4.5 (class statement: Sulphonylureas; "Fluconazole has been shown to prolong the serum half-life of concomitantly administered oral sulphonylureas (e.g. chlorpropamide, glibenclamide, glipizide, tolb") — electronic medicines compendium (UK SmPC)
Other interactions of Glyburide-metformin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Glyburide-metformin?
MediHelp rates the interaction as major. Fluconazole and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises glyburide concentrations and has been associated with significant hypoglycemia. The effect may be prolonged because fluconazole has a long half-life.
How serious is the interaction between Fluconazole and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after fluconazole therapy and reduce the glyburide dose in advance if possible. Consider an alternative antifungal or antidiabetic agent for prolonged courses.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
