Drug interactions
Fluconazole + Ibuprofen
Severity: Moderate
Fluconazole and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9, the main pathway for ibuprofen's active S-enantiomer, and can increase ibuprofen exposure. This may raise the risk of gastrointestinal and renal adverse effects.
What this interaction means in plain words
Fluconazole and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Ibuprofen belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated ibuprofen metabolism by fluconazole.
What to do
Use the lowest effective ibuprofen dose and limit duration. Monitor for GI bleeding, edema and renal effects, especially with high-dose or prolonged fluconazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Ibuprofen?
MediHelp rates the interaction as moderate. Fluconazole and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C9, the main pathway for ibuprofen's active S-enantiomer, and can increase ibuprofen exposure. This may raise the risk of gastrointestinal and renal adverse effects.
How serious is the interaction between Fluconazole and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ibuprofen dose and limit duration. Monitor for GI bleeding, edema and renal effects, especially with high-dose or prolonged fluconazole.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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