Drug interactions
Fluconazole + Ibutilide
Severity: Major
Fluconazole and Ibutilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide markedly prolongs repolarization and carries a substantial risk of torsades de pointes, and fluconazole can add to QT prolongation. The combination raises arrhythmia risk during and after ibutilide infusion.
What this interaction means in plain words
Fluconazole and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Ibutilide belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Avoid fluconazole around ibutilide cardioversion where possible. If it cannot be avoided, give ibutilide with continuous ECG monitoring and corrected potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Fluconazole with Ibutilide?
MediHelp rates the interaction as major. Fluconazole and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide markedly prolongs repolarization and carries a substantial risk of torsades de pointes, and fluconazole can add to QT prolongation. The combination raises arrhythmia risk during and after ibutilide infusion.
How serious is the interaction between Fluconazole and Ibutilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fluconazole around ibutilide cardioversion where possible. If it cannot be avoided, give ibutilide with continuous ECG monitoring and corrected potassium and magnesium.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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