Drug interactions
Fluconazole + Lemborexant
Severity: Major
Fluconazole and Lemborexant: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises lemborexant exposure, increasing risk of next-day somnolence, impaired psychomotor performance and other CNS effects. Labeling advises against moderate or strong CYP3A inhibitors.
What this interaction means in plain words
Fluconazole and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Lemborexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated lemborexant metabolism by fluconazole.
What to do
Avoid coadministration and choose an alternative hypnotic or antifungal. Counsel on next-day impairment if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Fluconazole with Lemborexant?
MediHelp rates the interaction as major. Fluconazole and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises lemborexant exposure, increasing risk of next-day somnolence, impaired psychomotor performance and other CNS effects. Labeling advises against moderate or strong CYP3A inhibitors.
How serious is the interaction between Fluconazole and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and choose an alternative hypnotic or antifungal. Counsel on next-day impairment if combined.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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