Drug interactions
Fluconazole + Lesinurad
Severity: Moderate
Fluconazole and Lesinurad: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP2C9 inhibitor and increases lesinurad exposure. Labeling advises caution because higher lesinurad levels may raise the risk of renal adverse effects.
What this interaction means in plain words
Fluconazole and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Lesinurad belongs to Genitourinary.
Why it happens
Fluconazole inhibits CYP2C9, reducing lesinurad metabolism.
What to do
Use lesinurad with caution and monitor renal function and serum creatinine. Consider an alternative antifungal or urate-lowering strategy if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Lesinurad?
MediHelp rates the interaction as moderate. Fluconazole and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP2C9 inhibitor and increases lesinurad exposure. Labeling advises caution because higher lesinurad levels may raise the risk of renal adverse effects.
How serious is the interaction between Fluconazole and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lesinurad with caution and monitor renal function and serum creatinine. Consider an alternative antifungal or urate-lowering strategy if renal function worsens.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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