Drug interactions
Fluconazole + Lumateperone
Severity: Moderate
Fluconazole and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises lumateperone exposure, which may increase sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Fluconazole and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Lumateperone belongs to Central Nervous System.
Why it happens
Fluconazole inhibits CYP3A4, which metabolizes lumateperone.
What to do
Reduce lumateperone to the labeled lower dose of 21 mg daily during concomitant moderate CYP3A4 inhibitor use. Monitor for sedation and blood pressure changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Fluconazole with Lumateperone?
MediHelp rates the interaction as moderate. Fluconazole and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole raises lumateperone exposure, which may increase sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Fluconazole and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to the labeled lower dose of 21 mg daily during concomitant moderate CYP3A4 inhibitor use. Monitor for sedation and blood pressure changes.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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