Drug interactions
Fluconazole + Meloxicam
Severity: Moderate
Fluconazole and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9 and CYP3A4, and meloxicam depends on these enzymes, so meloxicam exposure can increase. Higher levels may increase gastrointestinal, renal and bleeding adverse effects.
What this interaction means in plain words
Fluconazole and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Meloxicam belongs to Musculoskeletal.
Why it happens
Fluconazole inhibition of CYP2C9 (and CYP3A4) reduces meloxicam metabolism.
What to do
Use the lowest effective meloxicam dose and monitor for GI and renal adverse effects. Consider reducing the meloxicam dose during prolonged fluconazole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Meloxicam?
MediHelp rates the interaction as moderate. Fluconazole and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C9 and CYP3A4, and meloxicam depends on these enzymes, so meloxicam exposure can increase. Higher levels may increase gastrointestinal, renal and bleeding adverse effects.
How serious is the interaction between Fluconazole and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose and monitor for GI and renal adverse effects. Consider reducing the meloxicam dose during prolonged fluconazole therapy.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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