Drug interactions
Fluconazole + Metformin-pioglitazone
Severity: Moderate
Fluconazole and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C8 and CYP3A4, which can increase pioglitazone exposure. Higher levels may increase the risk of hypoglycemia, edema and weight gain, especially with prolonged fluconazole use.
What this interaction means in plain words
Fluconazole and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP2C8 and CYP3A4, reducing pioglitazone metabolism.
What to do
Monitor blood glucose and signs of fluid retention during concomitant use, and consider reducing the pioglitazone dose if fluconazole is continued long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Fluconazole and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C8 and CYP3A4, which can increase pioglitazone exposure. Higher levels may increase the risk of hypoglycemia, edema and weight gain, especially with prolonged fluconazole use.
How serious is the interaction between Fluconazole and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of fluid retention during concomitant use, and consider reducing the pioglitazone dose if fluconazole is continued long term.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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