Drug interactions
fluconazole + methadone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ methadone + QT prolongation risk.
Mechanism of action
CYP inhibition + additive QT.
Clinical management
Avoid or monitor; consider ECG surveillance.
Drug reference
References
Frequently asked questions
Can I take fluconazole with methadone?
The interaction is rated: Major. ↑ methadone + QT prolongation risk.
How serious is the interaction between fluconazole and methadone?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between fluconazole and methadone managed?
Avoid or monitor; consider ECG surveillance.
Why do fluconazole and methadone interact?
CYP inhibition + additive QT.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.