Drug interactions
Fluconazole + Nateglinide
Severity: Moderate
Fluconazole and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is metabolized mainly by CYP2C9 and partly by CYP3A4. Fluconazole inhibits CYP2C9 and may increase nateglinide exposure, raising the risk of hypoglycemia.
What this interaction means in plain words
Fluconazole and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Nateglinide belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP2C9 (and CYP3A4), decreasing nateglinide clearance.
What to do
Monitor blood glucose closely when starting or stopping fluconazole. Reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Fluconazole with Nateglinide?
MediHelp rates the interaction as moderate. Fluconazole and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide is metabolized mainly by CYP2C9 and partly by CYP3A4. Fluconazole inhibits CYP2C9 and may increase nateglinide exposure, raising the risk of hypoglycemia.
How serious is the interaction between Fluconazole and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping fluconazole. Reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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