Drug interactions
Fluconazole + Nelfinavir
Severity: Minor
Fluconazole and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir is metabolized by CYP3A4 and CYP2C19, and fluconazole can increase its exposure. The effect is generally modest and may enhance nelfinavir adverse effects such as diarrhea.
What this interaction means in plain words
Fluconazole and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Nelfinavir belongs to Anti Virals.
Why it happens
Fluconazole inhibits CYP3A4 and CYP2C19, slightly slowing nelfinavir metabolism.
What to do
No routine dose adjustment is needed; monitor tolerability, particularly gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluconazole with Nelfinavir?
MediHelp rates the interaction as minor. Fluconazole and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir is metabolized by CYP3A4 and CYP2C19, and fluconazole can increase its exposure. The effect is generally modest and may enhance nelfinavir adverse effects such as diarrhea.
How serious is the interaction between Fluconazole and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor tolerability, particularly gastrointestinal symptoms.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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