Drug interactions
Fluconazole + Nifedipine
Severity: Moderate
Fluconazole and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase nifedipine concentrations, leading to excessive vasodilation with hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Fluconazole and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Nifedipine belongs to Cardiovascular.
Why it happens
Fluconazole inhibits intestinal and hepatic CYP3A4 metabolism of nifedipine.
What to do
Monitor blood pressure and edema when starting or stopping fluconazole. Start nifedipine at a low dose and titrate carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Fluconazole with Nifedipine?
MediHelp rates the interaction as moderate. Fluconazole and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can increase nifedipine concentrations, leading to excessive vasodilation with hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Fluconazole and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when starting or stopping fluconazole. Start nifedipine at a low dose and titrate carefully.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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