Drug interactions
Fluconazole + Norgestrel
Severity: Minor
Fluconazole and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norgestrel is partly metabolized by CYP3A4, so fluconazole may modestly increase progestin exposure. The expected clinical effect is small, with possible increases in progestogenic adverse effects.
What this interaction means in plain words
Fluconazole and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Norgestrel belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4, slightly reducing norgestrel metabolism.
What to do
No dose adjustment is needed; counsel patients to report adverse effects such as breakthrough bleeding, nausea, or mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Fluconazole with Norgestrel?
MediHelp rates the interaction as minor. Fluconazole and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norgestrel is partly metabolized by CYP3A4, so fluconazole may modestly increase progestin exposure. The expected clinical effect is small, with possible increases in progestogenic adverse effects.
How serious is the interaction between Fluconazole and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; counsel patients to report adverse effects such as breakthrough bleeding, nausea, or mood changes.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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