Drug interactions
Fluconazole + Palovarotene
Severity: Major
Fluconazole and Palovarotene: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases palovarotene exposure and may amplify retinoid toxicity such as mucocutaneous effects, premature growth plate closure and hypervitaminosis A features.
What this interaction means in plain words
Fluconazole and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Palovarotene belongs to Miscellaneous.
Why it happens
Fluconazole inhibits CYP3A4, the primary metabolic pathway of palovarotene.
What to do
Avoid combining where possible; if unavoidable, reduce the palovarotene dose by half as labeled and monitor for retinoid toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Fluconazole with Palovarotene?
MediHelp rates the interaction as major. Fluconazole and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole increases palovarotene exposure and may amplify retinoid toxicity such as mucocutaneous effects, premature growth plate closure and hypervitaminosis A features.
How serious is the interaction between Fluconazole and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if unavoidable, reduce the palovarotene dose by half as labeled and monitor for retinoid toxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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