Drug interactions
Fluconazole + Pantoprazole
Severity: Minor
Fluconazole and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase pantoprazole exposure through CYP2C19 inhibition. Pantoprazole has a wide safety margin, so clinical consequences are generally minimal.
What this interaction means in plain words
Fluconazole and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Fluconazole inhibits CYP2C19 metabolism of pantoprazole.
What to do
No dose adjustment is usually required. Be aware of this in long-term high-dose proton pump inhibitor use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Fluconazole with Pantoprazole?
MediHelp rates the interaction as minor. Fluconazole and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may increase pantoprazole exposure through CYP2C19 inhibition. Pantoprazole has a wide safety margin, so clinical consequences are generally minimal.
How serious is the interaction between Fluconazole and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Be aware of this in long-term high-dose proton pump inhibitor use.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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