Drug interactions
Fluconazole + Pioglitazone
Severity: Minor
Fluconazole and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise pioglitazone levels because pioglitazone is metabolized by CYP2C8 and CYP3A4. This could increase fluid retention and hypoglycemia risk, though the effect is typically small.
What this interaction means in plain words
Fluconazole and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Pioglitazone belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4 (and CYP2C9) metabolism of pioglitazone.
What to do
Monitor blood glucose and signs of edema during co-therapy. Adjust the pioglitazone dose only if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Fluconazole with Pioglitazone?
MediHelp rates the interaction as minor. Fluconazole and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may raise pioglitazone levels because pioglitazone is metabolized by CYP2C8 and CYP3A4. This could increase fluid retention and hypoglycemia risk, though the effect is typically small.
How serious is the interaction between Fluconazole and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of edema during co-therapy. Adjust the pioglitazone dose only if clinically needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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