Drug interactions
Fluconazole + Repaglinide
Severity: Moderate
Fluconazole and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is cleared by CYP2C8 and CYP3A4. Fluconazole inhibits CYP3A4 and may raise repaglinide levels, increasing the risk of hypoglycemia.
What this interaction means in plain words
Fluconazole and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Repaglinide belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4, decreasing repaglinide metabolism.
What to do
Monitor blood glucose closely during co-therapy. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Fluconazole with Repaglinide?
MediHelp rates the interaction as moderate. Fluconazole and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is cleared by CYP2C8 and CYP3A4. Fluconazole inhibits CYP3A4 and may raise repaglinide levels, increasing the risk of hypoglycemia.
How serious is the interaction between Fluconazole and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-therapy. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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