Drug interactions
Fluconazole + Suvorexant
Severity: Moderate
Fluconazole and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole raises suvorexant concentrations, which may increase next-day somnolence and impaired alertness, including driving impairment.
What this interaction means in plain words
Fluconazole and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Suvorexant belongs to Central Nervous System.
Why it happens
Fluconazole inhibits CYP3A4, the main metabolic pathway for suvorexant.
What to do
Start suvorexant at 5 mg at bedtime and increase only if needed, up to the labeled maximum. Warn patients about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Fluconazole with Suvorexant?
MediHelp rates the interaction as moderate. Fluconazole and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole raises suvorexant concentrations, which may increase next-day somnolence and impaired alertness, including driving impairment.
How serious is the interaction between Fluconazole and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at 5 mg at bedtime and increase only if needed, up to the labeled maximum. Warn patients about next-day drowsiness.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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