Drug interactions
Fluconazole + Tadalafil
Severity: Moderate
Fluconazole and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole moderately inhibits CYP3A4 and can raise tadalafil exposure. This may increase headache, flushing, and hypotension.
What this interaction means in plain words
Fluconazole and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Tadalafil belongs to Genitourinary.
Why it happens
Fluconazole inhibits CYP3A4, reducing tadalafil clearance.
What to do
Use a lower tadalafil dose during fluconazole therapy and monitor tolerability and blood pressure. Prefer a single fluconazole dose over prolonged courses when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Tadalafil?
MediHelp rates the interaction as moderate. Fluconazole and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole moderately inhibits CYP3A4 and can raise tadalafil exposure. This may increase headache, flushing, and hypotension.
How serious is the interaction between Fluconazole and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower tadalafil dose during fluconazole therapy and monitor tolerability and blood pressure. Prefer a single fluconazole dose over prolonged courses when possible.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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