Drug interactions
Fluconazole + Telavancin
Severity: Moderate
Fluconazole and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, and fluconazole has been linked to torsades de pointes, especially at higher doses or with other risk factors. Using them together may raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Fluconazole and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Telavancin belongs to Anti Bacterial.
Why it happens
Additive prolongation of ventricular repolarization, with fluconazole blocking cardiac potassium channels.
What to do
Check a baseline ECG and monitor QTc and electrolytes during co-therapy. Correct hypokalemia and hypomagnesemia, and choose an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Telavancin?
MediHelp rates the interaction as moderate. Fluconazole and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, and fluconazole has been linked to torsades de pointes, especially at higher doses or with other risk factors. Using them together may raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Fluconazole and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc and electrolytes during co-therapy. Correct hypokalemia and hypomagnesemia, and choose an alternative if QTc becomes markedly prolonged.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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