Drug interactions
Fluconazole + Triamcinolone
Severity: Moderate
Fluconazole and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise triamcinolone exposure because triamcinolone is cleared through CYP3A4. Higher corticosteroid levels may cause Cushingoid features, adrenal suppression and hyperglycemia, especially with repeated or depot injections.
What this interaction means in plain words
Fluconazole and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Triamcinolone belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP3A4 (moderate inhibition), reducing the metabolic clearance of triamcinolone.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression, and consider reducing the triamcinolone dose or frequency if prolonged coadministration is needed. Be especially careful with repeated injections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluconazole and Triamcinolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Triamcinolone?
MediHelp rates the interaction as moderate. Fluconazole and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can raise triamcinolone exposure because triamcinolone is cleared through CYP3A4. Higher corticosteroid levels may cause Cushingoid features, adrenal suppression and hyperglycemia, especially with repeated or depot injections.
How serious is the interaction between Fluconazole and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression, and consider reducing the triamcinolone dose or frequency if prolonged coadministration is needed. Be especially careful with repeated injections.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
