Drug interactions
Fluconazole + Triptorelin
Severity: Moderate
Fluconazole and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fluconazole and androgen deprivation therapy with triptorelin are associated with QT interval prolongation. Used together they may increase the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Fluconazole and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation: fluconazole blocks cardiac potassium channels, and androgen deprivation lengthens the QT interval.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and avoid adding other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Fluconazole with Triptorelin?
MediHelp rates the interaction as moderate. Fluconazole and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both fluconazole and androgen deprivation therapy with triptorelin are associated with QT interval prolongation. Used together they may increase the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Fluconazole and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and avoid adding other QT-prolonging drugs where possible.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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