Drug interactions
Fluconazole + Vinorelbine
Severity: Moderate
Fluconazole and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase vinorelbine concentrations, potentially worsening neutropenia and neurotoxicity. The magnitude is not well characterised, and fluconazole is a moderate CYP3A4 inhibitor.
What this interaction means in plain words
Fluconazole and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Vinorelbine belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4, the main enzyme metabolising vinorelbine.
What to do
Monitor blood counts and signs of neuropathy or constipation during co-administration. Reduce the vinorelbine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Fluconazole with Vinorelbine?
MediHelp rates the interaction as moderate. Fluconazole and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase vinorelbine concentrations, potentially worsening neutropenia and neurotoxicity. The magnitude is not well characterised, and fluconazole is a moderate CYP3A4 inhibitor.
How serious is the interaction between Fluconazole and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy or constipation during co-administration. Reduce the vinorelbine dose if toxicity occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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