Drug interactions
Flucytosine + Valganciclovir
Severity: Moderate
Flucytosine and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause bone marrow suppression, and flucytosine is also nephrotoxic with renal accumulation. Combined use may increase the risk of cytopenias and worsen toxicity, so it warrants attention beyond a minor rating.
What this interaction means in plain words
Flucytosine and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flucytosine belongs to Anti Fungals; Valganciclovir belongs to Anti Virals.
Why it happens
Additive myelosuppression, with potential reduced flucytosine clearance if renal function declines.
What to do
Monitor complete blood counts and renal function frequently, and use flucytosine levels where available. Adjust doses to renal function and reduce or stop one agent if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flucytosine and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Valganciclovir
Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Deferiprone + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Fluconazole + Flucytosine Moderate
- Flucytosine + Ganciclovir Moderate
Frequently asked questions
Can I take Flucytosine with Valganciclovir?
MediHelp rates the interaction as moderate. Flucytosine and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause bone marrow suppression, and flucytosine is also nephrotoxic with renal accumulation. Combined use may increase the risk of cytopenias and worsen toxicity, so it warrants attention beyond a minor rating.
How serious is the interaction between Flucytosine and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function frequently, and use flucytosine levels where available. Adjust doses to renal function and reduce or stop one agent if cytopenias develop.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
