Drug interactions
Fludarabine + Trastuzumab deruxtecan
Severity: Moderate
Fludarabine and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and fludarabine is strongly myelosuppressive and immunosuppressive. Combined use raises the risk of severe neutropenia, febrile neutropenia and infection.
What this interaction means in plain words
Fludarabine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludarabine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload and the purine analogue.
What to do
Monitor blood counts frequently and treat or dose-modify for neutropenia; consider growth factor support and infection prophylaxis per local protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Belatacept + Fludarabine Major
- Dengue vaccine + Fludarabine Major
- Etrasimod + Fludarabine Major
- Fingolimod + Fludarabine Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Fludarabine with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Fludarabine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and fludarabine is strongly myelosuppressive and immunosuppressive. Combined use raises the risk of severe neutropenia, febrile neutropenia and infection.
How serious is the interaction between Fludarabine and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently and treat or dose-modify for neutropenia; consider growth factor support and infection prophylaxis per local protocols.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
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