Drug interactions
Fludrocortisone + Hydrochlorothiazide-irbesartan
Severity: Moderate
Fludrocortisone and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity and adds to the potassium loss from hydrochlorothiazide, risking hypokalemia. It also promotes sodium retention and can counteract blood pressure lowering.
What this interaction means in plain words
Fludrocortisone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting and opposing sodium retention from mineralocorticoid action.
What to do
Monitor serum potassium and blood pressure, and supplement potassium if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Fludrocortisone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity and adds to the potassium loss from hydrochlorothiazide, risking hypokalemia. It also promotes sodium retention and can counteract blood pressure lowering.
How serious is the interaction between Fludrocortisone and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and supplement potassium if required.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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