Drug interactions
Fludrocortisone + Levoketoconazole
Severity: Moderate
Fludrocortisone and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole strongly inhibits CYP3A4 and can raise fludrocortisone exposure. It also suppresses adrenal steroid synthesis, so effects on mineralocorticoid balance are hard to predict, with a risk of hypokalemia, hypertension and fluid retention.
What this interaction means in plain words
Fludrocortisone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4 and P-glycoprotein, reducing fludrocortisone clearance.
What to do
Monitor blood pressure, potassium and fluid status, and adjust the fludrocortisone dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fludrocortisone with Levoketoconazole?
MediHelp rates the interaction as moderate. Fludrocortisone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole strongly inhibits CYP3A4 and can raise fludrocortisone exposure. It also suppresses adrenal steroid synthesis, so effects on mineralocorticoid balance are hard to predict, with a risk of hypokalemia, hypertension and fluid retention.
How serious is the interaction between Fludrocortisone and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and fluid status, and adjust the fludrocortisone dose according to clinical response.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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