Drug interactions
Fludrocortisone + Lopinavir
Severity: Minor
Fludrocortisone and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids have been reported to weakly induce CYP3A4, which could modestly lower lopinavir exposure. The effect of fludrocortisone at usual replacement doses is likely small. Lopinavir/ritonavir may in turn raise corticosteroid exposure.
What this interaction means in plain words
Fludrocortisone and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Possible weak CYP3A4 induction by the corticosteroid; the effect is theoretical for fludrocortisone.
What to do
No routine adjustment is needed; monitor HIV viral load as part of standard care. Also watch for fluid retention, hypertension and hypokalemia because ritonavir-boosted lopinavir can increase fludrocortisone exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Fludrocortisone with Lopinavir?
MediHelp rates the interaction as minor. Fludrocortisone and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids have been reported to weakly induce CYP3A4, which could modestly lower lopinavir exposure. The effect of fludrocortisone at usual replacement doses is likely small. Lopinavir/ritonavir may in turn raise corticosteroid exposure.
How serious is the interaction between Fludrocortisone and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor HIV viral load as part of standard care. Also watch for fluid retention, hypertension and hypokalemia because ritonavir-boosted lopinavir can increase fludrocortisone exposure.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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