Drug interactions
Fludrocortisone + Ocrelizumab
Severity: Minor
Fludrocortisone and Ocrelizumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has mainly mineralocorticoid activity with only modest glucocorticoid immunosuppression at usual replacement doses. Any added infection risk with ocrelizumab is therefore small and relevant mainly at higher doses.
What this interaction means in plain words
Fludrocortisone and Ocrelizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Ocrelizumab belongs to Central Nervous System.
Why it happens
Weak additive immunosuppression from glucocorticoid activity of fludrocortisone on top of ocrelizumab B-cell depletion.
What to do
No dose change is generally needed at replacement doses. Stay alert for infection symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Ocrelizumab?
MediHelp rates the interaction as minor. Fludrocortisone and Ocrelizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has mainly mineralocorticoid activity with only modest glucocorticoid immunosuppression at usual replacement doses. Any added infection risk with ocrelizumab is therefore small and relevant mainly at higher doses.
How serious is the interaction between Fludrocortisone and Ocrelizumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed at replacement doses. Stay alert for infection symptoms.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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