Drug interactions
Fludrocortisone + Tiotropium-olodaterol
Severity: Moderate
Fludrocortisone and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fludrocortisone and olodaterol can lower serum potassium. Together they may cause clinically significant hypokalemia, which may provoke arrhythmias.
What this interaction means in plain words
Fludrocortisone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive potassium loss from mineralocorticoid-mediated renal excretion and beta2-driven cellular uptake.
What to do
Monitor serum potassium periodically and replace as needed. Take particular care in patients with heart disease or on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Fludrocortisone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both fludrocortisone and olodaterol can lower serum potassium. Together they may cause clinically significant hypokalemia, which may provoke arrhythmias.
How serious is the interaction between Fludrocortisone and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace as needed. Take particular care in patients with heart disease or on digoxin.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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