Drug interactions
Flunisolide inhaled + Posaconazole
Severity: Moderate
Flunisolide inhaled and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase systemic exposure to flunisolide. This could lead to corticosteroid effects such as Cushing's syndrome and adrenal suppression, mainly with prolonged use.
What this interaction means in plain words
Flunisolide inhaled and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces the metabolic clearance of swallowed and absorbed flunisolide.
What to do
Monitor for signs of corticosteroid excess during prolonged coadministration, and consider a less CYP3A4-dependent corticosteroid such as beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Flunisolide inhaled with Posaconazole?
MediHelp rates the interaction as moderate. Flunisolide inhaled and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase systemic exposure to flunisolide. This could lead to corticosteroid effects such as Cushing's syndrome and adrenal suppression, mainly with prolonged use.
How serious is the interaction between Flunisolide inhaled and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during prolonged coadministration, and consider a less CYP3A4-dependent corticosteroid such as beclomethasone.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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