Drug interactions
Fluoxetine + Furosemide
Severity: Moderate
Fluoxetine and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum sodium, so using them together increases the chance of hyponatremia. Older adults are at highest risk and may present with confusion, lethargy or falls.
What this interaction means in plain words
Fluoxetine and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced sodium loss combined with SSRI-associated SIADH produces additive hyponatremia.
What to do
Check serum sodium at baseline and after initiation, especially in elderly patients. Consider an alternative antidepressant if hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Furosemide?
MediHelp rates the interaction as moderate. Fluoxetine and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum sodium, so using them together increases the chance of hyponatremia. Older adults are at highest risk and may present with confusion, lethargy or falls.
How serious is the interaction between Fluoxetine and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after initiation, especially in elderly patients. Consider an alternative antidepressant if hyponatremia develops.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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