Drug interactions
Fluoxetine + Gemifloxacin
Severity: Moderate
Fluoxetine and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin can prolong the QT interval and fluoxetine has been linked to QT prolongation and torsades, particularly at higher exposures. Combined use may increase arrhythmia risk in patients with additional risk factors.
What this interaction means in plain words
Fluoxetine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization; fluoxetine also inhibits CYP2D6, though this is not relevant to gemifloxacin.
What to do
Check a baseline ECG in patients with cardiac risk factors and correct electrolyte abnormalities. Consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Gemifloxacin?
MediHelp rates the interaction as moderate. Fluoxetine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin can prolong the QT interval and fluoxetine has been linked to QT prolongation and torsades, particularly at higher exposures. Combined use may increase arrhythmia risk in patients with additional risk factors.
How serious is the interaction between Fluoxetine and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG in patients with cardiac risk factors and correct electrolyte abnormalities. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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