Drug interactions
Fluoxetine + Gilteritinib
Severity: Major
Fluoxetine and Gilteritinib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval, and fluoxetine can add to this effect, raising the risk of torsades de pointes. Gilteritinib's activity may also be affected by drugs that act at 5-HT2B or sigma receptors, but the clinical effect is uncertain.
What this interaction means in plain words
Fluoxetine and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluoxetine belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible pharmacodynamic receptor-level interference.
What to do
Avoid if another antidepressant can be used. Otherwise monitor ECG and electrolytes and reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Fluoxetine with Gilteritinib?
MediHelp rates the interaction as major. Fluoxetine and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib can prolong the QT interval, and fluoxetine can add to this effect, raising the risk of torsades de pointes. Gilteritinib's activity may also be affected by drugs that act at 5-HT2B or sigma receptors, but the clinical effect is uncertain.
How serious is the interaction between Fluoxetine and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if another antidepressant can be used. Otherwise monitor ECG and electrolytes and reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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