Drug interactions
Fluoxetine + Indacaterol-glycopyrronium
Severity: Moderate
Fluoxetine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval and indacaterol, a long-acting beta2-agonist, may add to cardiovascular effects and lower potassium. Concurrent use may modestly raise the risk of arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Fluoxetine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-agonist-related hypokalemia and sympathetic stimulation.
What to do
Monitor ECG in patients with cardiac risk factors or other QT-prolonging drugs, and correct potassium and magnesium abnormalities. Avoid exceeding recommended indacaterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Fluoxetine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval and indacaterol, a long-acting beta2-agonist, may add to cardiovascular effects and lower potassium. Concurrent use may modestly raise the risk of arrhythmia, particularly with other risk factors.
How serious is the interaction between Fluoxetine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors or other QT-prolonging drugs, and correct potassium and magnesium abnormalities. Avoid exceeding recommended indacaterol doses.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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