Drug interactions
Fluoxetine + Ivacaftor
Severity: Minor
Fluoxetine and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is metabolised mainly by CYP3A4, and fluoxetine is a weak CYP3A4 inhibitor, so ivacaftor exposure may rise slightly. The effect is generally modest because only strong and moderate inhibitors require dose changes.
What this interaction means in plain words
Fluoxetine and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Ivacaftor belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by fluoxetine may reduce ivacaftor clearance.
What to do
No dose adjustment is normally required; monitor for ivacaftor adverse effects such as raised transaminases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Fluoxetine with Ivacaftor?
MediHelp rates the interaction as minor. Fluoxetine and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is metabolised mainly by CYP3A4, and fluoxetine is a weak CYP3A4 inhibitor, so ivacaftor exposure may rise slightly. The effect is generally modest because only strong and moderate inhibitors require dose changes.
How serious is the interaction between Fluoxetine and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally required; monitor for ivacaftor adverse effects such as raised transaminases.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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