Drug interactions
Fluoxetine + Lasmiditan
Severity: Moderate
Fluoxetine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, which may be added to by other CNS-active drugs. Although it lacks vasoconstrictive activity, a theoretical serotonin syndrome risk is noted with serotonergic drugs such as fluoxetine.
What this interaction means in plain words
Fluoxetine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, and a theoretical additive serotonergic effect.
What to do
Advise patients not to drive for at least 8 hours after a lasmiditan dose and monitor for signs of serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Lasmiditan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Fluoxetine with Lasmiditan?
MediHelp rates the interaction as moderate. Fluoxetine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist that causes sedation and dizziness, which may be added to by other CNS-active drugs. Although it lacks vasoconstrictive activity, a theoretical serotonin syndrome risk is noted with serotonergic drugs such as fluoxetine.
How serious is the interaction between Fluoxetine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after a lasmiditan dose and monitor for signs of serotonin syndrome.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
