Drug interactions
Fluoxetine + Lomitapide
Severity: Moderate
Fluoxetine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine, through its metabolite norfluoxetine, is a weak CYP3A4 inhibitor and may raise lomitapide exposure. Higher lomitapide levels increase the risk of liver enzyme elevations and gastrointestinal adverse effects.
What this interaction means in plain words
Fluoxetine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of lomitapide.
What to do
Monitor liver enzymes closely and keep the lomitapide dose within the limit set in the labeling for patients taking weak CYP3A4 inhibitors. Reduce the dose if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Lomitapide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Fluoxetine with Lomitapide?
MediHelp rates the interaction as moderate. Fluoxetine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine, through its metabolite norfluoxetine, is a weak CYP3A4 inhibitor and may raise lomitapide exposure. Higher lomitapide levels increase the risk of liver enzyme elevations and gastrointestinal adverse effects.
How serious is the interaction between Fluoxetine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and keep the lomitapide dose within the limit set in the labeling for patients taking weak CYP3A4 inhibitors. Reduce the dose if transaminases rise.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
